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相关概念视频

Applications Of NMR In Biology01:25

Applications Of NMR In Biology

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Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
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NMR Spectrometers: Overview01:20

NMR Spectrometers: Overview

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NMR spectrometers consist of a strong magnet, a radiofrequency transmitter, and a detector attached to a computer console for recording spectra of samples containing NMR-active nuclei. In first-generation NMR instruments called continuous-wave spectrometers, the resonance frequencies of the nuclei are determined by frequency-sweep or field-sweep methods. The magnetic field strength is fixed and the rf signal is swept in the former, while the radiofrequency signal is fixed and the magnetic field...
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NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences01:17

NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences

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A pulse is a short burst of radio waves distributed over a range of frequencies that simultaneously excites all the nuclei in the sample. Upon passing a radio frequency pulse along the x-axis, the nuclei absorb energy corresponding to their Larmor frequencies and achieve resonance. This shifts the net magnetization vector from the z-axis toward the transverse plane. This angle of rotation of the magnetization vector, or the flip angle, is proportional to the duration and intensity of the pulse.
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Nuclear Magnetic Resonance (NMR): Overview01:07

Nuclear Magnetic Resonance (NMR): Overview

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Nuclear magnetic resonance (NMR) is a phenomenon exhibited by certain nuclei that can absorb characteristic radio frequency radiation under certain conditions. NMR has been extensively applied in molecular spectroscopy and medical diagnostic imaging. In both these applications, the molecule or subject under study is placed in a magnetic field and irradiated with radio frequency energy.
NMR spectroscopy generates a spectrum where the characteristic absorption frequencies of the sample are...
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    NMRFx是一种用于核磁共振 (NMR) 光谱数据分析的新软件. 它增强了各种科学领域的化学结构确定和分子动力学研究.

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    科学领域:

    • 化学学
    • 生物化学
    • 结构生物学
    • 代谢学

    背景情况:

    • 核磁共振 (NMR) 光谱对于确定各种分子系统的化学结构,动态和特性至关重要.
    • 对NMR数据的有效分析需要复杂的计算工具来处理,可视化和解释.
    • 现有的软件解决方案可能缺乏全面的NMR数据分析的集成或高级功能.

    研究的目的:

    • 推出一个新的,集成的NMR光谱数据分析软件NMRx.
    • 增强现有的处理,可视化和分析多样化的NMR实验数据的能力.
    • 通过各种科学领域的案例研究来证明NMRFx的实用性.

    主要方法:

    • 开发NMRViewJ和NMRViewX处理器的功能.
    • 实现高速,功能丰富的图形用户界面,以提高可用性.
    • 应用NMRFx在各种案例研究中,包括蛋白质,RNA,天然产品和代谢学分析.

    主要成果:

    • NMRFx可以实现高效的数据处理,峰值选择和分配.
    • 软件可以进行化学转移和分子结构计算.
    • 对复杂系统的成功应用,如泛素,RNA结构,塔卡洛诺利德E和藻类代谢学.

    结论:

    • NMRFx为NMR光谱数据分析提供了一个强大而通用的平台.
    • 该软件的功能超越现有工具,支持广泛的应用.
    • 通过NMRFx可以更深入地了解各个科学领域的分子结构和动态.