相关实验视频

Updated: Sep 9, 2025

Visualizing the Actin and Microtubule Cytoskeletons at the B-cell Immune Synapse Using Stimulated Emission Depletion STED Microscopy
11:00

Visualizing the Actin and Microtubule Cytoskeletons at the B-cell Immune Synapse Using Stimulated Emission Depletion STED Microscopy

Published on: April 9, 2018

14.0K

核形态和染色体组织调节T细胞细胞骨架重塑和免疫突触形成

Ivan A Rey Suarez, Aashli Pathni, Frank Fazekas

    bioRxiv : the preprint server for biology
    |September 5, 2025
    PubMed
    概括

    T细胞的激活包括核变化和动蛋白重组. 染色体紧缩影响T细胞的扩散和免疫突触的形成,揭示了细胞核和细胞骨之间的机械联系.

    更多相关视频

    Qualitative and Quantitative Analysis of the Immune Synapse in the Human System Using Imaging Flow Cytometry08:35

    Qualitative and Quantitative Analysis of the Immune Synapse in the Human System Using Imaging Flow Cytometry

    Published on: January 7, 2019

    11.7K
    An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics09:25

    An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics

    Published on: December 24, 2015

    9.1K

    相关概念视频

    Nucleosome Remodeling02:54

    Nucleosome Remodeling

    Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
    Nucleosome remodeling complex
    Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
    9.5K
    Chromatin Position Affects Gene Expression02:35

    Chromatin Position Affects Gene Expression

    Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
    Topologically Associated Domains (TADs)
    The 3-dimensional positioning of chromatin in the nucleus influences the...
    23.7K
    Assembly of Complex Microtubule Structures01:32

    Assembly of Complex Microtubule Structures

    Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
    1.9K
    T Cell Activation and Clonal Selection01:22

    T Cell Activation and Clonal Selection

    T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
    Naive T cells that have not yet encountered an antigen express two primary CD...
    4.4K
    Chromatin Modification in iPS Cells01:32

    Chromatin Modification in iPS Cells

    Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
    Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
    1.9K
    Regulation of Nuclear Protein Sorting01:45

    Regulation of Nuclear Protein Sorting

    Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
    2.4K