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Updated: Sep 9, 2025

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突触传输的多重变化是压力诱导的脑皮层持续激发的基础

Archana Proddutur, Daniel Jun Rindner, Ghalia Azouz

bioRxiv : the preprint server for biology

|September 5, 2025

概括

不断暴露于压力会损害神经元的持续发射, 这是由于大脑激发性和抑制性神经通信的组合变化造成的.

科学领域:

神经科学
认知科学
压力研究

背景情况:

压力会严重影响认知功能,包括注意力和工作记忆.
持续的神经元发射是支持这些认知过程的关键机制.
压力对持续的神经元活动的影响仍然很大程度上未知.

研究的目的:

研究重复应激如何影响后壁皮层 (PPC) 的第五层金字塔神经元 (L5 PNs) 的持续激发.
阐明导致持续神经活动变化的潜在神经机制.

主要方法:

在男性小鼠的急性大脑切片中利用计算建模和全细胞补丁电生理学.
研究了在青春期重复暴露于多种并发性压力因素 (aRMS) 对PPC中L5 PNs的影响.
分析了内在兴奋性,复发性连接性,谷氨酸性传播和GABAergic抑制.

主要成果:

aRMS 阻碍了 L5 PN 产生持续燃烧的能力.
暴露于压力对神经元刺激性和复发性连接性影响最小.
压力改变了激发性突触传递特性,并增加了PPC中GABAa和GABAb受体介导的抑制.
计算模型表明,改变激发和抑制突触传输的组合是复制压力诱导的持续发射的减少所必需的.

结论:

在青春期重复暴露会损害PPC中持续的神经元的激发.
增强的GABAergic抑制和改变的兴奋传输共同导致压力对持续神经活动的有害影响.
这些发现表明神经和电路功能的多面变化是压力对认知过程的影响的基础.

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