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Updated: Sep 9, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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通过 mitochondrial caspase 阻断,TP53 突变导致治疗耐药性

Ahmed M Mamdouh, Elyse A Olesinski, Fang Qi Lim

    bioRxiv : the preprint server for biology
    |September 5, 2025
    PubMed
    概括

    在急性髓性白血病 (AML) 中,TP53突变通过阻断酶激活而不是线粒体透,导致对 VenAza 治疗的耐药性. 这一发现揭示了克服TP53突变AML治疗耐药性的新治疗标.

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