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狗和人类共享死亡的生物标志物

Benjamin R Harrison, Joshua M Akey, Noah Snyder-Mackler

bioRxiv : the preprint server for biology

|September 5, 2025

概括

伴侣犬为人类衰老研究提供了有价值的模型. 预测狗的新陈代谢也预测人类的死亡,

科学领域:

老年学
代谢学
比较医学

背景情况:

对于预测人类的衰老,疾病风险和死亡率,
对于理解衰老生物标志物的转化研究模型存在重大差距.
现有的模型缺乏人类的遗传变异性,环境多样性和复杂的健康系统.

研究的目的:

研究伴侣狗作为人类衰老研究的转化模型的实用性.
确定人类和狗之间死亡的分子特征.
研究两种物种血代谢物与全因死亡之间的相关性.

主要方法:

来自"狗老化项目" (超过5万只狗) 的纵向生存数据的分析.
应用纵向生存模型来评估代谢物与死亡的关联.
在独立的人类研究中对代谢物与全因死亡率的比较.

主要成果:

在人类和狗中影响全因死亡的代谢物之间发现了强烈的,显著的正相关性.
鉴定的生物标志物在独立的人类研究中显示出很高的相关性,这表明了一般死亡率的特征.
血代谢组似乎保留了人类和狗的死亡特征.

结论:

伴侣犬是理解人类衰老的一个非常有价值的转化模型.
在新陈代谢中共享的死亡率突出显示了老化机制.
在狗身上进行进一步的研究可以阐明人类与年龄相关的发病率和死亡率的分子基础.

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