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Updated: Sep 9, 2025

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脂肪载体内皮细胞表现出与血脑屏障功能障碍,代谢重编程和老化大脑炎症增加相关的转录性特征

Sarah Otu-Boakye, Duraipandy Natarajan, Bhuvana Plakkot

bioRxiv : the preprint server for biology

|September 5, 2025

概括

衰老的大脑会在内皮细胞中积累脂质,从而损害血脑屏障的功能,并导致神经血管衰退. 这种脂质积累会影响细胞代谢并促进炎症,

科学领域:

神经科学
代谢研究
细胞衰老

背景情况:

脂质代谢失调与与年龄相关的疾病有关.
大脑内皮细胞 (ECs) 在衰老中的作用尚未得到充分研究.
质细胞一直是先前研究的主要焦点.

研究的目的:

研究老化大脑内皮细胞中的脂质积累.
确定脂质失调对ECs的影响.
探索大脑血管衰老的治疗目标.

主要方法:

从年轻和老老鼠大脑中获得的单细胞转录组数据的二次分析.
聚焦内皮细胞 (EC) 种群.
在体内验证脂质积累.

主要成果:

衰老会增加脑内脂肪滴的积累.
含有脂质的EC显示出血脑屏障功能受损,衰老和炎症.
变化的EC代谢包括脂肪酸氧化增加,糖分分解减少和线粒体活动受损.

结论:

脂质积累导致老化大脑EC的结构,功能和代谢缺陷.
内皮脂失调有助于脑血管衰老.
向脂质积累可以缓解与年龄相关的微血管功能障碍和认知衰退.

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