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Updated: Jun 9, 2026

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma
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自动图像细分揭示了CD74高的人类微质在认知衰退中的作用

Mariko Taga, Masashi Fujita, Neelang Parghi

    bioRxiv : the preprint server for biology
    |September 5, 2025
    PubMed
    概括

    微质中的高CD74表达与阿尔茨海默氏症痴呆症和认知衰退相关. 这些CD74高的微质表现出激活的,形形状,在阿尔茨海默病进展中连接转录和形态亚型.

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    相关概念视频

    Calmodulin-dependent Signaling01:16

    Calmodulin-dependent Signaling

    Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
    The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...