青春期大脑结构与认知能力之间的关联:对9至15岁儿童的全面大规模分析的见解
bioRxiv : the preprint server for biology
|September 5, 2025
概括
青少年大脑的发育显示出结构和认知的显著变化. 主要的大脑区域,尤其是额叶, 显示出与认知能力和与年龄相关的变化有最强的联系.
科学领域:
- 神经科学
- 认知科学
- 发展心理学
背景情况:
- 青春期是大脑结构和认知发展的关键时期.
- 此前对青少年大脑认知联系的研究面临样本大小和测量范围的局限性.
- 了解这些关联的年龄相关变化对于发展洞察至关重要.
研究的目的:
- 研究青少年大脑结构与认知能力之间的关联.
- 探索与年龄相关的大脑结构与认知关系的变化.
- 确定与认知能力相关的特定大脑区域和网络特征.
主要方法:
- 来自青少年大脑认知发展数据集的大型青少年队列的分析 (N=8,534,9-15岁).
- 使用结构MRI和扩散成像来得出区域和连接性大脑特征.
- 使用大规模计算模型来评估认知测试和一般智力 (g) 的关联.
主要成果:
- 主要在额叶,叶和叶的认知关联最强的大脑区域也显示出与年龄相关的最显著的变化.
- 与扩散成像指标相比,结构性MRI测量显示出更强的认知关联和更大的年龄相关变异性.
- 全球网络中心的措施与地方措施相比,与认知有更强烈和更可变的关联.
结论:
- 这项研究提供了青春期大脑结构与认知相关性的全面分析.
- 确定了认知发育及其与年龄相关的关键脑区域和网络特性.
- 为理解青少年基于大脑的认知发展提供了可靠的基础.
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