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在心肺旁路手术患者中,西普罗福对术后认知功能的影响:前性随机对照试验

Jun Lu¹, Yewei Shi¹, Xin Lan¹

¹Department of Anesthesiology, Affiliated Hospital of Guizhou Medical University, Guiyang, People's Republic of China.

Drug design, development and therapy

|September 5, 2025

概括

与普罗波相比,在心脏手术患者中,西普罗波显著降低了术后妄想. 然而,在手术后的1至3个月内,它没有影响长期的术后认知功能障碍.

科学领域:

麻醉学
心脏病学
神经科学

背景情况:

通过心肺绕道进行心脏手术,会导致术后认知功能障碍 (POCD) 和妄想 (POD) 的重大风险.
普罗波是一种常用的麻醉剂,但它对术后认知结果的影响需要进一步研究.
探索替代麻醉剂,如西普罗福,可能会改善神经保护效果.

研究的目的:

评估西普罗与普罗波相比降低手术后狂妄症 (POD) 的疗效.
在手术后的1个月和3个月评估西普罗对长期术后认知功能障碍 (POCD) 的影响.

主要方法:

这是一项前性随机对照性研究,涉及138名接受CPB心脏手术的患者.
患者被随机分为接受西普罗 (C组) 或普罗波 (P组) 进行麻醉诱导和维持.
使用混评估方法 (CAM) 或CAM- ICU评估术后妄想,使用电话蒙特利尔认知评估 (T- MoCA) 评估POCD1个月和3个月.

主要成果:

与醇组相比,POD的发生率明显较低 (29. 69%) (RR=0. 57;p=0. 009).
在1个月 (22. 03% vs 26. 62%; p = 0. 547) 或3个月 (16. 25% vs 16. 00%; p = 0. 771) 的POCD发病率中没有显著差异.
还监测了低血压,胆心梗塞和心动减速等不良事件.

结论:

在接受CPB心脏手术的患者中,Ciprofol有效降低了术后妄想的发生率.
西普罗福在1个月或3个月后对术后认知功能障碍的发生率没有显著影响.
减少POD可能有助于改善术后恢复,缩短住院时间,并可能缓解长期认知障碍.

关键词:

心脏外科手术通过心肺绕道其他:认知功能一种幻觉

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