口腔微生物群与妊娠糖尿病之间的因果关系:双样本孟德尔随机化研究
Hui Jin1, Yapei Wang1, Hongbin Li1
1Department of Internal Medicine, The Second People's Hospital of Nantong, Nantong, 226000, People's Republic of China.
International journal of women's health
|September 5, 2025
概括
孕期糖尿病 (GDM) 的风险与特定的口腔细菌属有因果关系. 口腔微生物群,包括Schaalia和Haemophilus,可能会影响GDM的发展,提供新的预防目标.
科学领域:
- 遗传学和微生物学
- 生殖健康和内分泌学
- 口腔健康和全身疾病
背景情况:
- 孕期糖尿病 (GDM) 与不良的妊娠结果有关.
- 口腔微生物群在GDM中的作用是可疑的,但并未因果确定.
- 遗传因素影响口腔微生物群的组成.
研究的目的:
- 研究口腔微生物群与GDM风险之间的因果关系.
- 确定与GDM相关的特定口腔细菌属.
- 为了利用孟德尔的随机化推理.
主要方法:
- 使用GWAS数据进行双样本门德尔随机化 (MR).
- 口腔微生物丰富度的仪器变量 (SNP).
- 反向差异加权 (IVW) 和强度敏感性分析.
主要成果:
- 在Schaalia属和增加的GDM风险之间发现了因果关系 (OR=1. 03).
- 在Haemophilus属和降低GDM风险 (OR=0. 96) 之间确定了因果关系.
- 敏感性分析证实了这些发现,排除了性和异质性.
结论:
- 口腔微生物群属Schaalia和Haemophilus与GDM风险存在因果关系.
- 口腔细菌可能在GDM发病过程中起作用.
- 这些发现表明GDM预防和治疗的潜在目标.
更多相关视频
09:09Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
Published on: August 17, 2022
1.8K
05:55Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
Published on: June 17, 2025
283
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.9K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.9K
Pathophysiology of Diabetes
1.2K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.2K
What is Monogastric Digestion?
72.4K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
72.4K
Anatomy of the Intestines
73.8K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
73.8K
