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Updated: Sep 9, 2025

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
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Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients

Published on: October 15, 2017

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优化含 ivacaftor 的固体脂质纳米颗粒以提高溶解度

Akshay Parihar1,2, Bhupendra G Prajapati3,4,5, Himanshu Paliwal6

  • 1Faculty of Pharmacy, Ganpat University, Mehsana, Gujarat, India.

Frontiers in pharmacology
|September 5, 2025
PubMed
概括

这项研究为Ivacaftor (IVF) 开发了优化的固体脂质纳米粒子 (SLN),用于治疗囊性纤维化 (CF). 这种配方表明药物释放有所改善,并有可能改善CF的治疗结果.

关键词:
CFTR调节器在体外溶解释放动力学固体脂质纳米粒子可溶性增强剂

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