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具有液体动力学诱导的液体-固体过渡的水凝,用于环状裂密封和微切除术后的炎症调节

Huan Wang¹, Moyan Li^2,3, Jiaojiao Yang²

¹Medical 3D Printing Center, Orthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, School of Basic Medical Sciences, Interdisciplinary Innovation Center for Nanomedicine, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215000, China.

Journal of orthopaedic translation

|September 5, 2025

概括

一种新的基于丝的粘合剂, 这种治疗可以减少炎症并防止进一步的退化,改善脊髓手术的结果.

科学领域:

生物材料科学
复原医学
脊椎外科的创新

背景情况:

椎间盘 (IVD) 导致腰部疼痛和残疾,微椎间盘切除作为标准治疗.
微隔膜切除术无法修复纤维环 (AF) 缺陷,因此存在复发性和IVD退化的风险.
目前对AF缺陷和相关炎症的治疗方法有限,需要新的治疗策略.

研究的目的:

开发和评估用于机械稳定和抗炎药物的可注射AF粘合剂.
评估STIG预防核脉突起和减轻IVD退化的能力.
研究STIG的潜力,以改善椎间盘的外科治疗结果.

主要方法:

STIG配方:丝纤维素,酸,伊布洛芬,瓜尼丁化物 (GuCl).
特性: 微观结构,组成,可注射性,粘附性,质,生物相容性.
在体外:用LPS刺激的AF细胞进行抗炎性评估.
在体内:用于评估STIG疗效的IVD退化的鼠尾模型.

主要成果:

在与体液接触时,STIG从注射液体转变为粘合凝.
在STIG中,ibuprofen有效地降低了炎症媒介和细胞外基质降解.
在体内,STIG保留了NP含水量,圆盘高度和IVD结构完整性.

结论:

STIG 显示为封闭 AF 裂和预防 IVD 退化的一种治疗方法.
这种粘合剂有望降低微椎间盘切除术后的复发率.
在脊椎外科手术中, STIG 提供了一种新的方法,

关键词:

椎间盘炎症发生可以注射的粘合剂预防措施水的刺激

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