基于网络药理学和实验验证的乙醇提取物的缓解机制
Songhao Tian1, Tao Chen2,3, Congying Song1
1Department of Medical Laboratory, Fenyang College of Shanxi Medical University, Fenyang, Shanxi, 032200, China.
Combinatorial chemistry & high throughput screening
|September 5, 2025
概括
乙醇提取物通过阿皮基宁通过减少炎症和抑制JAK- STAT通路来对抗与年龄相关的肌肉损失 (肉症). 这种天然化合物对治疗皮症有潜力.
科学领域:
- 自然产品化学
- 老年学
- 分子生物学
背景情况:
- 肌肉衰弱是一种与年龄相关的肌肉质量和功能下降.
- 是一种天然树脂, 具有抗炎性,
- 的特殊活性化合物和预防的机制尚不清楚.
研究的目的:
- 鉴定乙醇提取物 (PEE) 中针对的活性化合物.
- 阐明PEE对抗肉类的作用的分子机制.
- 研究PEE作为与年龄相关的肌肉退化自然干预的治疗潜力.
主要方法:
- 使用网络药理学来识别PEE和肉类的交叉目标.
- 通过蛋白质-蛋白质相互作用 (PPI) 和化合物-标预测 (CTP) 网络确定关键化合物和标,随后进行分子对接.
- 在体外研究中,在D- 银糖诱导的衰老的C2C12神经细胞上使用了apigenin (Ap),以评估细胞活力和西部抹迹.
主要成果:
- 确定了12个重叠的目标,其中TNFα和IL6被强调为关键.
- 鉴定出apigenin是PEE的主要活性化合物,具有强烈的与TNFα和IL6的结合亲和力.
- 原蛋白治疗增强了肌细胞活力,降低了TNFα和IL6,并抑制了JAK- STAT信号通路.
结论:
- 乙醇提取物主要通过阿皮根因,通过向炎症途径和抑制JAK-STAT信号来缓解.
- 这些发现为提供了一个分子基础,作为对的自然干预.
- 需要进一步的体内和临床研究来验证在与年龄相关的肌肉退化方面的治疗潜力.
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