基于纳米体的CAR-T在瘤免疫治疗中的应用 (综述)
Hongjing Liu1, Xueping Liu1, Xuyan Zhou2
1Department of Basic Medical Science, Guangxi Health Science College, Nanning, Guangxi Zhuang Autonomous Region 530023, P.R. China.
International journal of molecular medicine
|September 5, 2025
概括
基于纳米体的仿真抗原受体 (CAR) T细胞疗法在治疗癌症方面具有前景. 这些工程T细胞利用纳米体进行增强的向,在临床前和临床环境中显示出显著的治疗潜力.
科学领域:
- 免疫学
- 生物技术
- 癌症学
背景情况:
- 化学抗原受体 (CAR) T细胞治疗是一种精确的癌症免疫疗法.
- CAR-T细胞通过特定的膜受体向癌细胞.
- 来自驼类抗体的纳米体 (VHH) 提供了小尺寸和高亲和度等优势.
研究的目的:
- 探索纳米体在CAR T细胞治疗中的应用和潜力.
- 评估基于纳米体的CAR-T细胞用于治疗血液恶性瘤和固体瘤.
主要方法:
- 结构预先设计的纳米体被转化为初级T淋巴细胞以创建CAR-T细胞.
- 开发了各种纳米体CAR-T细胞模式,包括单,双价和多价结构.
- 对传统单链可变片段 (scFv) CAR- T 细胞进行了比较疗效研究.
主要成果:
- 基于纳米体的CAR- T细胞在体外和体内都表现出对癌细胞的抑制作用.
- 新型纳米体CAR-T细胞设计表现出双特异性和多特异性准能力.
- 使用抗BCMA纳米体进行的CAR- T细胞的疗效与基于scFv的CAR- T细胞相当.
结论:
- 纳米体是工程先进的CAR-T细胞的可行和有效组成部分.
- 基于纳米体的CAR-T疗法对未来的癌症治疗策略具有重大潜力.
- 纳米体CAR-T细胞的进一步开发可能会导致更复杂和更强大的治疗应用.
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