富含α-乳蛋白的低蛋白婴儿配方的免疫效应:一个随机对照试验
Ulrika T Nilsson1, Olle Hernell2, Bo Lönnerdal3
1Department of Clinical Sciences Malmö, Pediatrics, Lund University, Malmö, Sweden.
Journal of pediatric gastroenterology and nutrition
|September 5, 2025
概括
增加婴儿配方奶粉中的α- 乳蛋白并没有显著改变婴儿的免疫反应或感染率. 与配方奶粉养的婴儿相比,母乳养的婴儿的IL-6水平较低,因此需要进一步研究.
科学领域:
- 儿童营养
- 免疫学
- 胃肠病学
背景情况:
- 与配方奶粉养的婴儿相比,母乳养婴儿的感染风险较低.
- 母乳中的α-乳蛋白 (α-lac) 含量较高可能有助于婴儿肠道微生物群的健康.
- 研究婴儿配方中的α-lac度对免疫发育的影响至关重要.
研究的目的:
- 确定低蛋白婴儿配方中的α- 乳蛋白 (α- lac) 增加是否会影响免疫反应和感染发生率.
- 为了比较不同的婴儿配方奶粉与母乳中的α-lac含量.
- 在12个月以下的婴儿中评估免疫标志物和感染相关的发病率.
主要方法:
- 这是一项双盲随机对照试验,涉及2至6个月的245名健康婴儿.
- 婴儿接受了α-lac丰富的乳清,可赛因糖缩乳清或标准婴儿配方奶粉.
- 评估了细胞因子,高灵敏性C反应蛋白 (hsCRP) 和与感染相关的发病率.
主要成果:
- 与所有配方养组相比,母乳养婴儿的血清中白蛋白-6 (IL-6) 含量显著降低.
- 在其他测量细胞因子 (TNF-α,TGF-β1,TGF-β2,IL-1,IL-10,IL-12,INF-γ) 或hsCRP中没有显著差异.
- 在特定配方组与母乳之间,感染相关的发病率和抗生素使用仅有微小的差异.
结论:
- 在低蛋白婴儿配方中将α- lac度提高到母乳水平并没有显著影响细胞因子概况或感染率.
- 与配方奶粉养的婴儿相比,母乳养婴儿的IL-6水平较低,需要进一步调查.
- 目前用α-lac丰富的低蛋白配方对婴儿免疫结果和发病率的影响很小.
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