通过PI3K/AKT/mTOR途径改善小鼠肌肉缩
Yilei Li1,2, Peng Song1, Juan Wang3
1College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan 450046, China.
Food & function
|September 5, 2025
概括
蛋黄提取物
科学领域:
- 生物化学
- 肌肉生物学
- 营养科学
背景情况:
- 骨肌肉缩是一个重要的健康问题.
- 卵黄中负责肌肉发育的活性成分尚不清楚.
- 在肌肉消耗条件下研究自然化合物的治疗潜力至关重要.
研究的目的:
- 为了确定卵黄提取物中的维特洛根因2 (VTG2) 对肌肉缩的影响.
- 阐明VTG2在骨肌肉中的作用的分子机制.
- 探索VTG2的治疗潜力,
主要方法:
- 蛋白质组分析 (iTRAK) 用于识别卵黄提取物中的蛋白质.
- 关于神经细胞增殖和分化的体外研究.
- 在体内小鼠模型的德克萨米他和癌症缩诱导的肌肉缩.
- 信号通路的分析,包括PI3K/AKT/mTOR,自,炎症和线粒体功能.
主要成果:
- 在卵黄提取物中,Vitellogenin 2 (VTG2) 被确定为高度表达的蛋白质.
- 在体外,VTG2促进了肌细胞的增殖和分化.
- 在体内,VTG2改善了肌肉缩,改善了P- AKT水平,减轻了自,炎症和线粒体功能障碍.
- 确定PI3K/ AKT/ mTOR途径是VTG2作用的关键媒介.
结论:
- 受精卵黄提取物 (FEYE) 通过VTG2改善骨肌肉缩.
- VTG2通过PI3K/AKT/mTOR信号通路进行作用.
- 在预防和治疗肌肉缩相关疾病方面,VTG2具有显著的潜力.
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