代谢学揭示了与克罗恩病未来风险相关的不同分子途径
Mingyue Xue1, Sun-Ho Lee1,2, Jingchen Shao3
1Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada.
Gut microbes
|September 5, 2025
概括
健康亲属的早期代谢变化预测克罗恩病 (CD) 的发展. 较高的酸盐和较低的酸盐/异酸盐水平与未来的CD风险有关,突出显示了关键的代谢途径.
科学领域:
- 胃肠病学和免疫学
- 代谢学和微生物组研究
- 炎症性肠病的发生
背景情况:
- 在克罗恩病 (CD) 发病过程中,宿主微生物组的相互作用至关重要.
- 在CD发作之前的早期代谢变化还不清楚.
- 需要进行前性研究以确定临床前疾病特征.
研究的目的:
- 研究与未来CD发展相关的临床前代谢特征.
- 鉴定早期疾病发病过程中的特定代谢物和代谢途径.
- 探索新陈代谢特征,宿主因素和疾病标志物之间的关系.
主要方法:
- 在CCC-GEM项目队列中进行了嵌套病例对照研究 (5,122名健康一级亲属).
- 在78个未来的CD病例和311个匹配对照中分析了基线血清代谢特征.
- 不针对性代谢组与蛋白质组,微生物组和炎症标志物的综合性分析相结合.
主要成果:
- 鉴定出63种与未来疾病风险相关的代谢物.
- 在后来患有CD的个体中,酸 (酸) 含量升高,与炎症标志物 (CRP,便calprotectin,CXCL9) 相对应.
- 亚酸盐和异酸盐与降低的CD风险有关,与CRP和CD相关蛋白质有负相关性.
结论:
- 不同的分子途径有助于早期的CD病变.
- 代谢分析可以识别患有CD的高风险个体.
- 昆林酸盐,酸盐和异酸盐是CD风险和进展的潜在生物标志物.
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