多发性硬化症和相关疾病患者的长期COVID:多中心横断研究
Chen Hu1, Jiyeon Son2, Lindsay McAlpine3
1Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Annals of clinical and translational neurology
|September 5, 2025
概括
患有多发性硬化症和相关疾病的人患长期COVID的几率更高,尤其是症状恶化. 长期的COVID显著恶化了这一群体的功能和残疾.
科学领域:
- 神经学
- 传染性疾病
- 公共卫生
背景情况:
- 在患有多发性硬化症和相关疾病 (pwMSRD) 的人群中,由于症状重叠,长期COVID的管理存在挑战.
- 现有证据缺口需要对长期COVID易感性及其对pwMSRD的影响进行研究.
研究的目的:
- 与对照组相比,评估pwMSRD的长期COVID易感性.
- 评估长期COVID与pwMSRD多领域功能和残疾之间的关联.
主要方法:
- 一项涉及969名pwMSRD和1003名对照者的多中心横截面研究.
- 参与者完成了71个感染后症状的调查,区分新发症状和恶化症状.
- 使用2024年NASEM标准定义了长COVID;采用了后勤和回归分析.
主要成果:
- 在PwMSRD中,长期COVID的几率更高 (aOR=1.6),症状恶化的相关性更强 (aOR=2.3).
- 长期的COVID与两个群体的身体功能,认知能力和抑郁症增加有关.
- 长期COVID患者的功能下降,抑郁症恶化,残疾进展更快.
结论:
- 患有PwMSRD的人表现出对长期COVID的易感性增加,主要是由症状恶化驱动的.
- 长期的COVID显著导致pwMSRD的功能衰退和残疾恶化.
- 早期识别和管理长期COVID对于改善pwMSRD的结果至关重要.
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