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Controlled Cortical Impact Model for Traumatic Brain Injury
Published on: August 5, 2014
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在创伤性脑损伤后,infliximab是否可以减轻氧化压力?
Ömer Şahin1, Fatma Karaca Kara2
1Department of Brain and Nerve Surgery, Bestepe State Hospital, Ankara-Türkiye.
概括
在创伤性脑损伤后减少氧化应激时,Infliximab 具有类似的神经保护作用. 然而,infliximab在减少脑方面更有效.
科学领域:
- 神经科学
- 生物化学
- 药理学
背景情况:
- 创伤性脑损伤 (TBI) 是一个重大的全球健康挑战.
- 一种抗炎药物Infliximab用于治疗各种系统性炎症.
- 这项研究研究了德克萨梅他松和因弗利西马布在老鼠模型上的TBI的影响.
研究的目的:
- 为了比较德克萨梅他松和因弗利西马布给药后头受伤的老鼠的病理和生化变化.
- 评估Infliximab在TBI引起的损伤方面的神经保护作用.
- 评估这些治疗对氧化应激标志物和的影响.
主要方法:
- 三十二只成年大鼠被分为四组:假药,对照 (创伤),德克萨梅他松治疗和因弗利西马布治疗.
- 在创伤后立即分别用甲松 (1 mg/ kg) 和用皮下注射 (5 mg/ kg).
- 在创伤后七天,对脑组织进行了分析,以检测马隆迪阿尔海德 (MDA),超氧化脱氧化酶 (SOD) 和谷过氧化酶 (GPx) 的含量,并进行了瘤病理检查.
主要成果:
- 在四组中观察到大脑组织MDA,SOD和GPx水平的统计学显著差异.
- 在INFLIXIMAB和德克萨梅他松组之间没有发现MDA,SOD和GPx度的显著差异.
- 病理分析显示,与对照组相比,INFLIXIMAB组的皮质损伤,间歇性和周围血管减少.
结论:
- 在创伤后,因弗力西马布对氧化应激标志物具有与甲基沙相似的神经保护作用.
- 与德克萨米松相比,因弗利克西马比在TBI后减少水形成方面表现出更好的效果.
- 这些发现表明,因弗利西玛是治疗TBI相关并发症的潜在药物.
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