针对COVID-19疫苗的免疫反应与中国传统医学的构成之间的相关性
Ping Chen1, Hung-Rong Yen1,2,3,4, Hui-Ju Lee2,3,5
1School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan.
Human vaccines & immunotherapeutics
|September 5, 2025
概括
传统中医药 (TCM) 的成分会影响COVID-19疫苗的免疫反应,特别是细胞免疫和不良反应,但不会影响抗体水平. 这表明基于TCM类型的个性化疫苗策略.
科学领域:
- 免疫学
- 个性化医疗
- 传统中国医学
背景情况:
- 传统中国医学 (TCM) 将个人分为不同的体型.
- 这些成分可能会影响生理反应和免疫系统活动.
- COVID-19 疫苗会引起免疫反应,包括抗体和细胞免疫.
研究的目的:
- 调查TCM体型与COVID-19疫苗接种免疫反应之间的关联.
- 探索TCM构成与疫苗接种后不良事件之间的相关性.
- 确定TCM构成是否影响疫苗诱导的抗体产生和细胞免疫力.
主要方法:
- 在接种两剂COVID-19疫苗之前和之后,从78名成年人身上收集了周围血液单核细胞 (PBMC).
- 评估免疫参数,包括细胞因子,抗体标位,树突细胞 (DC),T细胞,B细胞和记忆T细胞子集.
- 使用"中医宪法问卷" (CCMQ) 确定了中医宪法类型,并分析了与免疫反应和不良事件的相关性.
主要成果:
- 疫苗接种前的TNF-α水平与温和性和qi缺陷构成相关.
- 在特定的TCM组成组中,DC和T细胞的比例增加.
- 在TCM成分和抗体水平或中和之间没有发现显著的相关性.
- 湿,气压和血液静止的人群中,不良反应更为频繁.
结论:
- 在接种COVID-19疫苗后,TCM构成类型与细胞免疫反应和不良反应概况有关.
- 在接种疫苗后,TCM成分似乎没有影响抗体的产生.
- 整合TCM构成框架可能有助于个性化疫苗反应预测和管理.
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