通过调节miR-9-3p/Hippo信号轴,HBV编码的circRNA-5促进肝细胞癌的进展
Yong Yang1,2, Yongshi Shen3, Yuan Dang1,2
1Innovation Center for Cancer Research, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.
Microbiology spectrum
|September 5, 2025
概括
乙型肝炎病毒 (HBV) 的 circRNA-5 通过促进细胞生长和扩散来驱动肝癌 (HCC). 这种HBV circRNA针对miR-9-3p,激活YAP/TAZ和Hippo通路,为HBV相关的HCC提供新的治疗点.
科学领域:
- 肝病学和病毒瘤学
- 分子生物学与致癌
背景情况:
- 慢性乙型肝炎病毒 (HBV) 感染仍然是全球的主要健康问题,导致肝脏疾病和肝细胞癌 (HCC).
- 尽管接种了疫苗,但仍有数百万人面临HBV相关肝脏并发症的风险,而导致HCC发展的分子机制尚未完全理解.
研究的目的:
- 研究HBV编码的循环RNA (circRNA) 在HBV介导的HCC的发病过程中的作用.
- 阐明HBV促进HCC进展的分子机制.
主要方法:
- 为了评估HBV-circRNA-5的功能,进行了体外和体内实验.
- 机制研究涉及分析HBV-circRNA-5,miR-9-3p和YAP/TAZ信号通路之间的相互作用.
主要成果:
- 在实验室中,HBV-circRNA-5的过度表达显著促进了HCC细胞的增殖和转移.
- 在体内,HBV-circRNA-5增强了HCC瘤的生长.
- 在机理上,HBV-circRNA-5被发现结合miR-9-3p,导致YAP/TAZ上调和随后通过Hippo网络的HCC扩散.
结论:
- 在HBV相关的HCC的发展和进展中,HBV-circRNA-5是关键的驱动因素.
- HBV-circRNA-5/miR-9-3p/Hippo路径代表了HBV诱导的致癌的新机制.
- 这项研究确定了治疗HBV相关HCC的潜在治疗点.
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