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Oliver Aasmets¹, Nele Taba¹, Kertu Liis Krigul¹

¹Institute of Genomics, Estonian Genome Centre, University of Tartu, Tartu, Estonia.

|September 5, 2025

概括

长期使用药物,包括抗生素和抗抑郁药, 显著影响肠道微生物群. 这些效应在使用后持续多年,强调在微生物组研究中考虑药物历史的重要性.

科学领域:

微生物组研究
药理学
人类健康

背景情况:

药物使用是肠道微生物组变化的关键因素.
之前的研究往往忽略了药物对微生物的长期和累积影响.
过去的药物消费对肠道微生物群的影响越来越被认可.

研究的目的:

系统地评估抗生素和人群向药物的长期影响.
研究药物对肠道微生物组成的添加剂和延续效应.
探索药物使用与微生物组变化之间的潜在因果关系.

主要方法:

利用电子健康记录中的药物使用数据.
分析了来自爱沙尼亚微生物群的形基因组学数据 (n = 2,509).
用纵向微生物组数据检查了一个子队列 (n = 328),以评估治疗开始/停止后的变化.

主要成果:

过去的药物使用,包括抗生素,精神病药,抗抑郁药,质子抑制剂和β-阻断剂,与肠道微生物组有显著的关联.
这些药物诱导的微生物组变化在停止使用后的几年内仍可检测到.
在开始治疗和停止治疗时都观察到类似的微生物组变化,这表明可能存在因果关系.

结论:

这项研究使用详细的电子健康记录数据首次对药物对肠道微生物的长期影响进行了系统评估.
对各种药物类别,包括抗生素,二衍生物,抗抑郁药和糖皮质激素,确定了携带作用和添加作用.
这些发现强调了多种药物对肠道微生物组的附带影响,并强调需要将药物历史纳入疾病微生物组关联研究.

关键词:

抗生素抗抑郁药物青类药物贝塔抑制剂药物处方使用毒品其他药物电子健康登记肠道微生物组针对人类的药物长期药物影响其他药物基因组学心理治疗药物

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