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内膜网的激活所需的矮体开放式读取框架的结构元素

M'Lynn E Fisher1, Justin R Gregory1, Stan T J Aanhane1

  • 1Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.

Biochemistry
|September 5, 2025
PubMed
概括

矮开放式读取框架 (DWORF) 激活了肉质内膜 (SERCA). 在DWORF中的特定残留物对这种激活至关重要,突变导致SERCA抑制,揭示了SERCA调节的关键结构洞察力.

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