[精子氧化降低潜力,精子DNA片段和精子参数之间的关联]
Xiao-Chuan Guan1, Yue-Xin Yu1, Ning Zhang1
1Reproduction Medicine Center, General Hospital of Northern Theater Command, Shenyang, Liaoning 110003, China.
Zhonghua nan ke xue = National journal of andrology
|September 5, 2025
概括
精子氧化降低潜力 (nORP) 在静脉患者中较高,与精子DNA碎片化 (DFI) 增加和精子质量降低相关. 这表明nORP可能表明氧化应激影响男性生育能力.
科学领域:
- 生殖生物学
- 雄性学
- 氧化应激研究
背景情况:
- 这是男性不孕症的常见原因.
- 氧化应激与精子功能受损有关.
研究的目的:
- 调查精子氧化减少潜力 (nORP),精子DNA碎片化 (DFI) 和精子参数之间的关系.
- 评估nORP作为静脉中氧化应激的潜在标志物.
主要方法:
- 对522名男性的临床数据进行了回顾性分析 (静脉 n=116,非静脉 n=406).
- 分组间的精液血nORP,DFI,高DNA染色能力 (HDS) 和精液参数的比较.
- 在静脉患者中,nORP与精液参数,DFI和HDS的相关性分析.
- 基于静脉的严重程度 (轻度,中度,严重) 的差异分析.
主要成果:
- 静脉患者的精子数量,度,渐进性运动率 (PR%) 和正常形态 (NSMR) 显著下降.
- 精液中的nORP,DFI和HDS在静脉患者中显著较高.
- nORP与精子数量,度,NSMR有负相关性,与DFI和HDS有正相关性.
- 在瘤严重程度组中观察到nORP,精子参数,DFI和HDS的显著差异.
结论:
- 精液中的nORP可能是静脉中氧化应激的关键指标.
- 增加的nORP与DFI增加和精液质量降低有关.
- nORP可以作为评估瘤患者男性生育能力的有价值生物标志物.
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