身体活动对神经认知障碍患者认知功能的益处:系统性审查
Théodore Decaix1, Claire Bonnin2, Karl Götze3
1Geriatrics Department, Fernand Widal Lariboisière University Hospital, GHU APHP.Nord, 75010 Paris, France; Paris-Cité University, Inserm U1144, Paris, France.
The Journal of frailty & aging
|September 5, 2025
概括
定制体育活动对阿尔茨海默症和帕金森症等神经退行性疾病的认知功能有好处. 个性化的运动计划对于优化这些积极效果至关重要.
科学领域:
- 神经科学
- 老年学
- 运动生理学
背景情况:
- 神经认知障碍显著损害功能能力,特别是在老年人中.
- 身体活动是增强神经退行性疾病认知能力的一种有前途的非药物治疗方法.
- 针对各种神经认知疾病需要量身定制的干预措施.
研究的目的:
- 审查身体活动对阿尔茨海默病,血管认知障碍,帕金森病和莱维体痴呆症患者的认知功能的影响.
- 评估相关研究的方法严谨性,参与者特征,运动类型和认知结果.
- 确定神经认知障碍管理的最佳体力活动策略.
主要方法:
- 关于身体活动和神经认知障碍的21项研究的文献综述.
- 分析研究设计,参与者人口统计,运动干预措施 (有氧运动,抵抗等). ),以及认知评估.
- 报告的认知和功能结果的评估.
主要成果:
- 在21项研究中,14项报告了体育炼对认知功能,特别是有氧活动的有益影响.
- 在认知表现和身体功能方面观察到改善,尽管效果大小小小,结果各不相同.
- 建议的机制包括降低粉样蛋白/蛋白负担,改善葡萄糖代谢,在阿尔茨海默病中增加BDNF,以及在帕金森病中调节多巴胺通路.
结论:
- 身体活动是支持神经退行性疾病的重要非药物干预措施.
- 由于研究的可变性,需要针对特定条件量身定制的个性化炼计划.
- 需要进一步研究以确定长期影响,最佳方式和标准化的评估标准.
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