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相关概念视频

Kidney Transplant I: Introduction01:28

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Tissue Transplantation01:24

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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从SARS-CoV-2阳性捐赠者移植心脏后的安全性和1年结果:国际分析的见解

Sabina P W Guenther1, Josephine Wadewitz2, Brian J Wayda3

  • 1Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, Ruhr-University Bochum, Bad Oeynhausen, Germany.

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概括

从SARS-CoV-2阳性捐赠者的心脏移植是安全的,在一年的存活率或不良心血管事件中没有差异. 这种方法扩大了心脏移植 (HT) 的捐赠人群.

关键词:
COVID-19 的捐赠者SARS-CoV-2 的捐赠者捐赠者的特征心脏移植移植结果

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科学领域:

  • 心脏病学
  • 病毒学
  • 移植免疫学

背景情况:

  • 关于使用SARS-CoV-2阳性捐献者的心脏进行心脏移植 (HT) 的安全性和有效性存在不确定性.
  • 评估国际队列的结果对于建立器官捐赠和移植的最佳实践至关重要.

研究的目的:

  • 评估使用SARS-CoV-2阳性供体器官进行心脏移植的1年结果和安全性.
  • 将这些结果与来自SARS-CoV-2阴性捐赠者的心脏移植进行比较.

主要方法:

  • 使用美国 (UNOS注册) 和德国 (DSO) 的SARS-CoV-2阳性捐赠者的心脏移植的国际回顾性分析.
  • 纳入标准:在器官恢复之前的确定的时间内呈SARS-CoV-2阳性的捐赠者.
  • 数据收集集中在1年移植和接受者的生存率,急性排斥率,再住院和特定不良事件上.

主要成果:

  • 在美国,来自SARS-CoV-2阳性捐赠者的心脏移植 (n=274) 与阴性捐赠者 (n=3952) 相比,急性拒绝率较低 (10.6%对17.1%).
  • 在两组之间,一年的移植存活率,接受者存活率和再住院率没有显著差异.
  • 在德国,SARS-CoV-2阳性心脏接受者 (n=23) 的一年存活率为91.3%,没有心肌炎或血栓栓塞的病例.

结论:

  • 选择的SARS-CoV-2阳性供体心脏可以安全地用于心脏移植.
  • 移植似乎不会增加 SARS-CoV-2 从捐赠者传播给接受者的风险.
  • 没有观察到1年存活率或心血管不良事件的显著差异,支持扩大这些器官的使用.