腺病毒视网膜炎:一种常见病毒的罕见病例
Nyaish Mansoor1, Emma A Davies2, Dominic A Haigh2
1Manchester Royal Eye Hospital, Manchester University NHS Foundation Trust, Manchester, UK.
Ocular immunology and inflammation
|September 5, 2025
概括
人类腺病毒D (HAdV-D) 在骨髓移植后的患者中引起死亡视网膜炎的罕见病例. 静脉注射cidofovir在治疗这种HAdV视网膜炎方面表现出有效性,突出了诊断和治疗方面的考虑.
科学领域:
- 眼科 眼科
- 病毒学
- 免疫学
背景情况:
- 死亡视网膜炎是一种严重的眼睛疾病.
- 免疫功能低下的患者容易发生机会性感染.
- 人类腺病毒 (HAdV) 感染可能出现在眼睛中.
研究的目的:
- 记录一种可能由新型HAdV-D引起的双边死视网膜炎的罕见病例.
- 探索诊断障碍和静脉注射西多福维尔的疗效.
- 审查有关HAdV视网膜炎的现有文献.
主要方法:
- 追溯案例报告分析.
- 对水体和玻璃体样本进行聚合酶链反应 (PCR) 测试.
- 用于HAdV识别的基因组测序.
- 用静脉注射西多福维尔治疗和脏监测.
主要成果:
- 一位骨髓移植后的患者出现了对经验性抗病毒药物不反应的双边死性视网膜炎.
- 检测到高HAdV负载,后来被确定为潜在的新型HAdV-D.
- 静脉注射cidofovir导致HAdV负载减少和视网膜痕的临床改善.
- 眼睛之间最终的视力敏度有显著差异.
结论:
- 在免疫受损的个体中,应怀疑HAdV视网膜炎的发生,这种视网膜炎对标准抗病毒药物无反应.
- 静脉注射cidofovir可以作为HAdV视网膜炎的有效非标签治疗方法.
- 连续的水性PCR对于监测HAdV视网膜炎的治疗反应很有价值.
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