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相关概念视频

Nature and Nurture01:10

Nature and Nurture

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Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
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Role of Hematopoietic Growth Factors01:28

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Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
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Signs of Puberty01:27

Signs of Puberty

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Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
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Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

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Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
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Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

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Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
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Hormones and Bone Tissue01:17

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
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Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
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对于生长激素缺乏儿童的生长激素治疗报告结果的趋势

Xanthippi Tseretopoulou1,2, Jiajia Chen3, Angela Lucas-Herald1,2

  • 1Developmental Endocrinology Research Group, University of Glasgow, Royal Hospital for Children, Glasgow, UK.

The Journal of clinical endocrinology and metabolism
|September 5, 2025
PubMed
概括

本综述分析了儿童的生长激素治疗结果. 最常见的是身高和安全性指标,这表明需要为生长激素缺乏症 (GHD) 治疗制定标准化的核心结果.

关键词:
核心成果有效性增长激素安全性

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科学领域:

  • 儿童内分泌学
  • 药物监督管理
  • 临床试验方法

背景情况:

  • 儿童生长激素缺乏症 (GHD) 是一种严重的内分泌疾病.
  • 重组人体生长激素 (rhGH) 治疗是儿童群体中GHD的主要治疗方法.
  • 了解报告结果的范围对于优化rhGH治疗至关重要.

研究的目的:

  • 系统地回顾GHD儿童治疗的安全性和有效性结果的频率和趋势.
  • 确定 rhGH 治疗研究中最常被评估的参数.
  • 为儿童GHD制定标准化的核心结果.

主要方法:

  • 在2003年至2022年间在英语和中文数据库中发表的研究的系统审查.
  • 纳入标准:参与者在16岁之前开始使用rhGH.
  • 数据提取集中在报告的结果,研究设计和参与者人口统计学上.

主要成果:

  • 包括219个研究 (171个队列,39个受控试验,9个病例对照).
  • 最常见的结果:身高SDS (53%),身高速度 (48%),IGF-1 (30%) 和注射部位的不良反应 (20%).
  • 超过50%的结局侧重于安全性,有效性结局也经常报告;生活质量结局是罕见的 (3%).

结论:

  • 在过去二十年中,高度SDS和高度速度一直是最常见的疗效结果.
  • 报告的结果中很大一部分与安全性有关,包括不良事件和生化标志物.
  • 这些发现支持开发和实施一套核心结果,用于对患有GHD的儿童进行一致的评估.