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通过肠道微生物群调节逆转Farnesoid X受体淘汰小鼠的代谢失调

Ines Leila Paraiso^1,2, Armando Alcázar Magaña^1,2,3, Alexandra Alexiev⁴

¹Department of Pharmaceutical Sciences, Oregon State University, Corvallis, Oregon, United States of America.

|September 5, 2025

概括

通过改变肠道细菌来防止肥胖. 在高脂肪饮食的小鼠中,Xanthohumol是一种FXR配体,恢复了肠道健康和代谢平衡.

科学领域:

代谢调节
肠道微生物组
药理学

背景情况:

法内索伊德X受体 (FXR) 调节葡萄糖和脂质代谢.
FXR调节是一种潜在的肥胖治疗方法.
区分肠道和肝脏的FXR作用是药物开发的关键.

研究的目的:

评估肠道FXR对高脂肪饮食 (HFD) 的小鼠肠道微生物群的影响.
评估香醇对FXR信号和肠道健康的影响.
确定山托醇的基因型特异性影响.

主要方法:

肠道FXR敲击小鼠模型.
高脂肪饮食 (HFD) 养
肠道微生物组合和功能能力分析.
在Xanthohumol治疗中.

主要成果:

肠道FXR敲击可以预防饮食引起的肥胖.
缺少FXR改变了肠道微生物群,减少了有益细菌 (例如Akkermansia),增加了二次胆汁酸生产者 (例如Oscillospira).
桑托醇减轻了这些微生物组的变化,并恢复了新陈代谢平衡.

结论:

在HFD下,肠道FXR在调节肠道微生物群和新陈代谢方面发挥着至关重要的作用.
桑托荷摩尔可以改善肠道健康和代谢功能障碍.
这些发现突出了针对肠道FXR和肠道微生物组的治疗策略.

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