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Updated: Sep 8, 2025

Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs
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Published on: September 10, 2017

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双酸酶逆行反增强了TCR信号和自身免疫

Shen Yang1,2, Eugenio Santelli1,2, Carlos G Gonzalez3,4

  • 1Department of Medicine, Altman Clinical and Translational Research Institute, University of California, San Diego, La Jolla, CA 92093, USA.

Science advances
|September 5, 2025
PubMed
概括

在Ser449的蛋白氨酸酸酶非受体类型22 (PTPN22) 酸化增强T细胞信号和自身免疫力. 这个PTPN22位点在狼中过化,表明它是自身免疫性疾病的治疗点.

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