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Pedro G Vieira¹, Matthew R Krause¹, Pooya Laamerad¹

¹Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

Science advances

|September 5, 2025

概括

大脑刺激,特别是间交流电刺激 (tACS),似乎主要影响长距离的神经预测. 这一发现表明神经刺激可能针对网络连接, 需要重新评估当前的策略.

科学领域:

神经科学
计算神经科学
神经刺激

背景情况:

大脑刺激的进步允许越来越多的焦点电磁刺激针对特定的神经区域.
大脑的广泛相互连接引发了关于神经预测是否特别容易受到刺激的问题.
了解刺激对神经网络的影响对于开发有效的治疗措施至关重要.

研究的目的:

调查长距离神经投射是否比其他神经元更容易受到跨交替电流刺激 (tACS).
要确定刺激是否优先影响网络连接 (边缘) 与单个神经元 (节点).

主要方法:

在接受tACS的非人类灵长类动物中使用单单元记录.
根据电生理性质识别出可能的远程发射神经元.
分析了对tACS反应的神经引模式.

主要成果:

与其他记录的细胞相比,假设的远程预测对tACS表现出明显更强的吸引力.
这些预测导致了极强的神经连接.
证据表明tACS影响神经网络边缘比节点更大.

结论:

神经刺激,特别是tACS,可能优先针对神经元之间的连接,而不是神经元本身.
目前的神经刺激策略可能需要重新设计,以考虑神经网络拓学的影响.
需要进一步研究以充分阐明刺激对神经网络动态的影响.

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