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功能丧失突变确保对免疫检查点治疗的反应是NOD2

Ana C Anderson1,2, Manu Rangachari3,4

  • 1Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA.

Science immunology
|September 5, 2025
PubMed
概括

在癌症患者中,NOD2基因的功能丧失突变可能表明对PD-1阻断免疫治疗的反应更好. 这一发现可能有助于个性化癌症治疗策略.

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