在COVID-19患者中患有急性病. 拉丁美洲的前性多中心多国研究
Raúl Lombardi1, Alejandro Ferreiro1, Yanissa Venegas2
1Universidad de la República, Facultad de Medicina, Centro de Nefrología, Montevideo, Uruguay.
Jornal brasileiro de nefrologia
|September 5, 2025
概括
急性病 (AKD) 影响超过75%的COVID-19患者,与蛋白尿和急性损伤 (AKI) 相关的死亡率更高. 这突出了AKD
科学领域:
- 肝脏病学
- 传染性疾病
- 危急护理医学
背景情况:
- 急性病包括90天内的异常.
- COVID-19 呈现功能障碍,包括蛋白尿和功能丧失.
- 评估AKD为这些条件提供了更合适的框架.
研究的目的:
- 评估住院COVID-19患者急性病 (AKD) 的患病率和影响.
- 使用AKD标准对功能障碍进行分类,包括蛋白尿和急性损伤 (AKI).
- 分析AKD严重程度与住院死亡率之间的关系.
主要方法:
- 一个观察性的,前性的,纵向的,跨国队列研究.
- 包括五个拉丁美洲国家的成年COVID-19患者.
- 将患者分为四种AKD类别:没有病,只有蛋白尿,只有AKI,以及蛋白尿和AKI组合.
主要成果:
- 75.8%的COVID-19患者表现出AKD.
- 在72. 8%的患者中存在蛋白尿,在36. 4%的患者中存在AKI.
- 随着AKD的严重程度,住院死亡率显著增加,从9.5%增加到53%以上.
结论:
- 这项研究支持使用急性病 (AKD) 概念的综合方法.
- 为了更好的管理,AKD提供了AKI,AKD和CKD的连续性.
- 这种方法有助于及时干预和预防功能障碍.
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