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Updated: Apr 7, 2026

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基于外体的GPIHBP1mRNA输送系统的工程,以有效治疗家族高甘油血症

Ying Cao1,2, Xiao Meng1,2, Xinxin Xu1,2

  • 1The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong 271000, China.

Journal of medicinal chemistry
|September 5, 2025
PubMed
概括

这项研究引入了一种基于外体的疗法,用于向糖酸氨酸定高密度脂蛋白结合蛋白1 (GPIHBP1) 提供mRNA,有效治疗小鼠的家族高甘油三血症 (FHTG).

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Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
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