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深度乳液溶剂:改善 Plantago asiatica L. (PAL) 提取物在老鼠中的口服吸收
Chuanhua Feng1, Xiaolin Tang2, Jian Zhou1
1Department of Pharmacy, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, P. R. China.
Chemistry & biodiversity
|September 5, 2025
概括
深溶解剂 (DES) 改善了 Plantago asiatica L. (PAL) 成分的吸收和体内度. 这表明DES可能会增强PAL提取物的治疗效果.
科学领域:
- 药物动力学
- 自然产品化学
- 分析化学
背景情况:
- 亚洲植物 (PAL) 是一种广泛使用的和药用草本.
- 了解PAL成分的药物动力学特征对于优化其治疗潜力至关重要.
- 深度溶解剂 (DES) 正成为一种新型辅助剂,有可能提高药物输送效果.
研究的目的:
- 研究胆酸DES对PAL提取物中关键成分的药理动力学的影响.
- 开发和验证一种敏感的UHPLC-MS/MS方法,用于量化大鼠血中的七种PAL分析物.
- 为了比较DES和水中的PAL提取物的药理学参数.
主要方法:
- 开发和验证与三重四极质谱法 (UHPLC-MS/MS) 结合的超高性能液体色谱法.
- 在老鼠血中同时定量素,烯酸,乌尔索酸,维巴斯科西德,阿皮基宁,奥库和植物.
- 在1%的DES (v/v) 或水中溶解的PAL提取物口服给老鼠.
主要成果:
- 一种敏感和特定的UHPLC-MS/MS方法已成功建立和验证.
- 与水相比,当提取物溶于15%的DES时,七种PAL分析物的药用动力学参数 (Cmax,AUC0- t,AUC0- ∞) 显著更高.
- 服用DES会增加PAL成分的吸收并使其在体内存在时间延长.
结论:
- 深度溶解剂 (DES) 显著提高了 Plantago asiatica L. 提取物成分的口服生物可用性.
- 通过增加其活性化合物的吸收和作用时间,DES可以提高PAL的治疗效果.
- 这项研究强调了DES作为PAL等天然产品的配方策略的潜力.
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