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Updated: Sep 8, 2025

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
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Published on: June 8, 2022

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基于1,2,4-oxadiazole的高度选择性和强大的S1PR1激动剂的发现和SAR研究

Tianyu Ye1, Jinling Yu1, Yuxian Fang1

  • 1School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.

European journal of medicinal chemistry
|September 5, 2025
PubMed
概括

研究人员开发了一种选择性Sphingosine-1-phosphate受体1 (S1PR1) 激动剂Y18,用于治疗免疫疾病. Y18具有很高的选择性,有可能减少与其他S1PR1药物发生的胸肌梗塞等副作用.

关键词:
一,二,四氧化一个S1PR1激动剂S1PR1内部化选择性

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