在美国一般人口中暴露于甲状腺功能风险的挥发性有机化合物:2007-2012年NHANES
1Xiangya School of Public Health, Central South University, Changsha 410078, China.
Ecotoxicology and environmental safety
|September 5, 2025
概括
对挥发性有机化合物 (VOC) 的暴露会影响甲状腺功能,特别是在女性和老年人身上. 这项研究强调VOC是甲状腺功能障碍的危险因素,需要监测和监管.
科学领域:
- 环境健康
- 内分泌学
- 毒理学
背景情况:
- 环境危害与甲状腺功能之间存在着确定的联系.
- 对一般人群中挥发性有机化合物 (VOC) 和甲状腺功能的证据有限.
- 甲状腺激素 (FT3,FT4) 和它们的比例是甲状腺健康的关键指标.
研究的目的:
- 研究单个和组合的VOC暴露对甲状腺功能的影响.
- 在美国普通人口样本中分析甲状腺激素水平 (FT3,FT4) 和FT4/FT3比率.
- 确定导致甲状腺功能变化的特定VOC.
主要方法:
- 使用权重定量总和 (WQS) 回归来评估VOC的联合效应.
- 分析了来自美国普通人口的代表性样本的数据.
- 根据性别和年龄 (≥60岁) 进行分组分析.
主要成果:
- 同时暴露于VOC与FT3呈正相关性,与FT4/FT3比率呈负相关性.
- 1,4-二二是FT3升高的主要原因.
- 四乙烯,二甲基和对FT4/FT3的降低有所贡献.
- 在女性和60岁及以上的个体中观察到显著的关联.
- 特定的VOC如乙,1,4-二和o-xylen被确定为这些子组的关键贡献者.
结论:
- 暴露于VOC会对甲状腺功能产生负面影响,特别是在女性和老年人 (≥60岁) 中.
- 挥发性有机化合物可能加速甲状腺功能障碍并改变甲状腺激素水平.
- 这些发现支持对VOC进行早期监测和监管策略,以减轻甲状腺功能障碍的发生率.
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