儿童半球切除术患者的双向和不对称的平滑追踪缺陷
Maria Z Chroneos1, Marlene Behrmann2, J Patrick Mayo3
1Carnegie Mellon University, Department of Psychology, Pittsburgh PA 15213, USA; University of Pittsburgh, School of Medicine, Medical Scientist Training Program, Pittsburgh PA 15213, USA.
概括
在半球切除术后,患者表现出光滑的追踪眼动受损,但通过改变的动特征来补偿. 这表明单个半球可以产生追求, 但完整的水平追求需要双边大脑互动.
科学领域:
- 神经科学
- 眼科 眼科
- 大脑皮层
背景情况:
- 眼睛运动的神经回路已知,但半球在眼球运动控制中的作用尚不清楚.
- 了解半球对平稳追逐的贡献对于理解视觉运动整合至关重要.
研究的目的:
- 调查单个半球对平面顺追求的贡献的必要性和充分性.
- 描述儿童半球切除术患者的眼运动控制缺陷和补偿机制.
主要方法:
- 在儿童半球切除术后的14名患者中评估了水平平滑追踪.
- 将患者的眼睛运动 (平滑的追逐,跳动) 与年龄相匹配的对照进行比较.
- 排除了感觉 ( Hemianopia) 和一般运动障碍作为缺陷的唯一原因.
主要成果:
- 患者表现出双边,不对称的平滑追踪缺陷,眼睛的速度降低和升高.
- 不对称的"追赶"冲动伴随着非典型的追赶,在患者中观察到更快的冲动,特别是在位上.
- 这些发现不论是哪个半球被切除都是一致的.
结论:
- 一个单一的大脑半球可以产生平稳的追求和补偿行为.
- 在大规模的皮质干扰后, 没有发现固有的半球偏差来支持追踪.
- 完整的水平顺追求可能需要在两个半球的综合神经电路.
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