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Updated: Sep 8, 2025

Characterization of In Vitro Differentiation of Human Primary Keratinocytes by RNA-Seq Analysis
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素异构的综合性分析

Nicole Schwarz1, Rudolf E Leube1, Stefan Düsterhöft2

  • 1Institute of Molecular and Cellular Anatomy, RWTH Aachen University, Wendlingweg 2, Aachen 52074, Germany.

European journal of cell biology
|September 5, 2025
PubMed
概括

这项研究使用计算建模揭示了质素异构化的关键结构原理. 质二元体具有有利的相互作用和特定的结构特征,这些特征对中间丝组件很重要.

关键词:
阿尔法倍数器中间纤维质素氨酸异构化

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相关概念视频

Disassembly of Intermediate Filaments01:35

Disassembly of Intermediate Filaments

Intermediate filaments (IFs) do not undergo spontaneous disassembly. Enzymes, kinases, and phosphatases add and remove phosphates from specific sites to regulate their disassembly. The IF concentration in the cytoplasm also regulates the disassembly. If the concentration crosses a threshold, it activates the protein kinases in the vicinity, allowing the phosphorylation of IFs.
Keratin proteins, found at the cell periphery near cell junctions, undergo a cycle of assembly and disassembly. In Type...
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