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COVID-19 流行病对黑色素瘤的影响:来自法国黑色素瘤患者临床数据库 (RIC-Mel) 的回顾性研究
F Skowron1, S Mouret2, A Seigneurin3
1Hôpitaux Drôme Nord, Romans-Sur-Isère, France.
Annales de dermatologie et de venereologie
|September 5, 2025
概括
法国COVID-19大流行导致了更严重的黑色素瘤诊断,瘤变得更厚,更发. 这部分是因为在疫情期间发现的黑色素瘤较少.
科学领域:
- 癌症学
- 皮肤病学
- 流行病学
背景情况:
- COVID-19 疫情对各种疾病的临床表现和严重程度产生了不同的影响.
- 黑色素瘤是一种重要的皮肤癌, 需要及时诊断和治疗以获得最佳结果.
- 了解与流行病相关的医疗服务中断对于治疗黑色素瘤等慢性和严重疾病至关重要.
研究的目的:
- 调查COVID-19流行病对法国黑色素瘤病例初始诊断严重性的影响.
- 在疫情前和疫情期间比较黑色素瘤特征和诊断时间表.
- 评估COVID-19时代瘤厚度,和病期的变化.
主要方法:
- 来自法国RIC-Mel数据库的新黑色素瘤病例的回顾性分析.
- 包括三个不同的时间框架:COVID前,封锁和更广泛的COVID大流行时期 (2020年5月11日至2022年9月30日).
- 在COVID前和COVID期间,患者和黑色素瘤特征的统计比较,包括瘤阶段,和治疗时间.
主要成果:
- 与COVID前期相比,COVID期间诊断的黑色素瘤显著更厚 (1.5毫米相比1.2毫米),并且的发生频率更高 (25.4%相比20.6%).
- 观察到黑色素瘤的每日诊断率有所下降,特别是薄型黑色素瘤 (Tis和T1阶段).
- 在COVID期间,晚期瘤 (T2,T3,T4) 和III期黑色素瘤诊断显著增加,同时哨戒淋巴结活检率和阳性率增加.
结论:
- 法国COVID-19大流行与严重黑色素瘤诊断的比例较高有关.
- 一个关键因素似乎是发现和诊断较薄,较不发达的黑色素瘤的减少.
- 这些发现凸显了公共卫生危机期间癌症早期诊断延迟或错过的可能性.
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