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纳米生物反应器检测与太空相关的造血干细胞和祖细胞衰老

Jessica Pham¹, Jane Isquith¹, Larisa Balaian¹

¹Sanford Stem Cell Institute Integrated Space Stem Cell Orbital Research (ISSCOR) Center, Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA.

|September 5, 2025

概括

太空飞行加速了人类干细胞的衰老. 这项研究使用先进的生物反应器来证明太空旅行会破坏细胞循环并导致突变,

科学领域:

太空生物学和天体生物学
造血干细胞生物学
老龄化研究

背景情况:

太空飞行对人类健康构成风险,
之前的研究表明在太空暴露后免疫系统功能障碍.
太空飞行对造血干细胞和原生细胞 (HSPC) 衰老的具体影响尚未研究.

研究的目的:

研究太空飞行对人类老化的影响.
鉴定由于太空暴露导致的HSPC分子和细胞变化.
评估这些变化对长期太空飞行的影响.

主要方法:

开发具有FUCCI2BL报告器的骨髓利基纳米生物反应器,用于实时HSPC跟踪.
使用人工智能驱动的 CubeLabs 在国际空间站 (ISS) 进行实验.
使用全基因组测序,转录组测序,细胞因子阵列和HSPC-FOMA分析.

主要成果:

观察到细胞循环,炎症细胞因子,线粒体基因,人类重复元素和APOBEC3的放松.
在太空飞行的HSPC中发现了克隆性造血突变.
证实端粒维护减少,自我更新基因表达受损 (ADAR1 p150),并降低了重叠能力.

结论:

太空飞行显著加速人类的衰老.
这些发现表明人类长期探索太空的潜在局限性.
这项研究为太空诱导的细胞衰老机制提供了关键的见解.

关键词:

其他类型在APOBEC 年龄增长细胞周期克隆性血液形成黑色的基因组造血干细胞和原生细胞低地球轨道纳米生物反应器重复的元素

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