一个多通道集成的听觉功能测试系统
Shijie Xiao1, Yihang Zheng2, Guanting Lin3
1Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China.
Neuroscience
|September 5, 2025
概括
我们开发了一种新的听觉脑干响应 (ABR) 系统, 这种高通量系统提高了听力功能评估的效率并扩展了听力损失研究.
科学领域:
- 神经科学
- 听觉神经科学
- 听力研究
背景情况:
- 听觉脑干反应 (ABR) 对于评估人类和动物模型的听觉功能至关重要.
- 关键的ABR特征 (值,波幅/延迟) 有助于诊断和理解听力损失机制.
- 越来越多的基因工程小鼠模型需要高通量ABR测试.
研究的目的:
- 开发一种高通量ABR系统,以有效地对小鼠进行听觉表型识别.
- 克服现有的单个动物,低采样率系统的局限性.
- 能够进行先进的听觉测量,包括高频DPOAE和CM.
主要方法:
- 开发了一个四通道的ABR系统,用于同时测试四个受试者.
- 集成一个定制的声室,用于小鼠听觉频率>50dB的噪声减弱.
- 用于高频记录 (>32 kHz) 的增强声学和电气性能.
主要成果:
- 新系统复制了TDT测量的ABR值,波I延迟和振幅.
- 与现有系统相比,测试吞吐量增加了三倍.
- 启用高频扭曲产品的音响发射 (DPOAE) 和耳麦克风 (CM) 记录.
结论:
- 开发的ABR系统满足了大量听觉研究的需求.
- 提供卓越的效率和扩展功能评估能力.
- 在下一代研究中提供可扩展,高保真的听觉表型平台.
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