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在社区生活的老年人中,血清维生素D代谢物水平与认知功能之间的关联:横截面研究
Cai Yu1, Minae Ide1, Taiki Sugimoto2
1Department of Nutrition, Graduate School of Human Life and Ecology, Osaka Metropolitan University, 2-1-132, Osaka-shi, Osaka 536-8525, JAPAN.
维生素D的代谢物超过了25...OH) D,为认知健康提供了新的见解. 特定的代谢物和比例与认知功能和阿尔茨海默病风险存在性别相关性.
科学领域:
- 神经科学与内分泌学
- 维生素D代谢的生物化学
背景情况:
- 维生素D缺乏与认知衰退和阿尔茨海默病 (AD) 有关,但研究结果不一致.
- 总的25-维生素D [25(OH) D]可能无法完全捕捉维生素D的作用;其他代谢物,如24,25-二维生素D3 [24,25(OH) 2D3]和3-epimer-25-维生素D3 [3-epi-25(OH) D3]可能更具信息性.
研究的目的:
- 研究血清维生素D代谢物度与老年人的认知功能之间的关联.
- 探索这些关联中的潜在性别差异.
主要方法:
- 对289名患有AD,轻度认知障碍 (MCI) 或认知正常 (CN) 的成年人进行横截研究.
- 通过微型心理状态检查 (MMSE) 评估认知功能.
- 用LC-MS/MS测量的25 (OH) D3,25 (OH) D2,24,25 (OH) D3,3-epi-25 (OH) D3和1,25-二维生素D3的血清度. 计算了维生素D代谢物比率 (VMR).
主要成果:
- 在男性中,3-epi-25 ((OH) D3) 和24,25 ((OH) D3) 与较低的MMSE得分和较高的AD风险有关.
- 在女性中,VMR与较高的MMSE得分和较低的AD风险有关,而1,25(OH) 2D3与较高的AD风险有关.
- 在维生素D代谢物与认知的关系中观察到基于性别的差异.
结论:
- 维生素D与认知的性别差异可能受到荷尔蒙因素的影响.
- 代谢物如1,25(OH) 2D3,VMR和3-epi-25(OH) D3可能是比总25(OH) D更敏感的认知健康指标.
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