在被认为是B组慢性阻塞性肺病的住院患者使用吸入器的评估
Noah S Ball1, Eric M Kinney1, Erin McMahan1
1WVU Medicine - WVU Hospitals; Morgantown, WV.
Journal of the American Pharmacists Association : JAPhA
|September 5, 2025
概括
在B组慢性阻塞性肺病 (COPD) 患者中,由于药物制剂的限制,不适当使用吸入性皮质类固醇 (ICS) 是常见的. 这增加了诸如肺炎等不良事件的风险,凸显了更好地使用吸入器的需要.
科学领域:
- 肺部医学
- 药物经济学
- 临床药房
背景情况:
- 建议在B组慢性阻塞性肺病 (COPD) 治疗中使用长效肌酸抗体 (LAMA) 和长效β抗体 (LABA).
- 吸入性皮质类固醇 (ICS) 在这一群体中可能没有益处,并增加风险.
- 住院药剂限制可能导致不适当的ICS使用和不良反应.
研究的目的:
- 在被认为是B组COPD患者的住院ICS处方的适当性.
- 确定ICS相关不良事件的发生率.
主要方法:
- 在100名疑似患有B组COPD的患者中进行了回顾性队列研究.
- 从2022年7月到2023年9月使用的电子健康记录数据 (EPIC).
- 排除了先前有ICS的患者,最近的恶化,喘或没有药物调和.
主要成果:
- 14% 的患者接受了违反GOLD指导方针的ICS治疗.
- 在这些患者中,有14%的患者出现了潜在的ICS相关肺炎.
- 吸入器的可用性可能会影响不适当的ICS处方.
结论:
- 住院患者的药剂限制可能导致B组慢性肺炎患者不适当使用ICS.
- 缺乏LAMA/LABA吸入器可能会导致ICS的使用.
- 解决形式限制对于优化COPD管理至关重要.
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