使用外部数据采集和线性过从不连续的PerceptTMPC和RC输出重建时间域数据
Jinxin Chen1, Mandy M Koop2, Kenneth B Baker3
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States of America.
Journal of neuroscience methods
|September 5, 2025
概括
在Medtronic深度大脑刺激 (DBS) 记录中发现了时间错误,并使用了新的算法进行了纠正. 这种方法提高了对长期DBS数据分析的时间同步的准确性.
科学领域:
- 神经科学
- 生物医学工程
- 信号处理
背景情况:
- 梅特罗尼克的PerceptTM PC和RC深度大脑刺激 (DBS) 系统提供了记录功能.
- 在DBS记录过程中刺激频率的变化引入时间域细分和时间错误.
- 准确的时间数据对于分析DBS期间的神经活动至关重要.
研究的目的:
- 在Medtronic PerceptTM PC和RC DBS记录中量化时间错误.
- 开发和验证用于纠正这些时间错误的算法.
- 为了在DBS数据中实现精确的时间同步,特别是在长时间的录音中.
主要方法:
- 使用PerceptTM DBS导线进行了ex-vivo局部现场潜力记录.
- 刺激频率发生变化,与外部黄金标准刺激器测量时间差异.
- 基于观察到的错误模式和真实频率变化事件,开发了一种新的算法来纠正时间变化.
主要成果:
- 在PC和RC系统中都观察到显著的定时错误,其特点是有牙图案和线性坡道的突然下降.
- 原始定时误差为PC的-400ms和RC的-1至1s.
- 开发的算法成功地将计时误差降低到PC的-10.07±45.06ms和RC的-23.52±17.32ms.
结论:
- 这项研究成功地描述和量化了Medtronic DBS记录中的时间错误.
- 一个新的算法有效地纠正这些时间错误, 显著提高时间准确性.
- 这种方法可在体内使用,可能使用脑电图,以提高长期DBS数据分析的可靠性.
相关概念视频
Reconstruction of Signal using Interpolation
330
Signal processing techniques are essential for accurately converting continuous signals to digital formats and vice versa. When a continuous signal is sampled with a period T, the resulting sampled signal exhibits replicas of the original spectrum in the frequency domain, spaced at intervals equal to the sampling frequency. To handle this sampled signal, a zero-order hold method can be applied, which creates a piecewise constant signal by retaining each sample's value until the next...
330
Aliasing
224
Accurate signal sampling and reconstruction are crucial in various signal-processing applications. A time-domain signal's spectrum can be revealed using its Fourier transform. When this signal is sampled at a specific frequency, it results in multiple scaled replicas of the original spectrum in the frequency domain. The spacing of these replicas is determined by the sampling frequency.
If the sampling frequency is below the Nyquist rate, these replicas overlap, preventing the original...
If the sampling frequency is below the Nyquist rate, these replicas overlap, preventing the original...
224
Impulse Response
343
The impulse response is the system's reaction to an input impulse. In an RC circuit, the voltage source is the input, and the capacitor's voltage is the output. The system's state and output response before and after input excitation are distinctly defined.
Kirchhoff's law forms an input signal equation, with the capacitor's current and voltage providing the output. Substituting the current and dividing by RC yields a differential equation. The output for an impulse input is...
Kirchhoff's law forms an input signal equation, with the capacitor's current and voltage providing the output. Substituting the current and dividing by RC yields a differential equation. The output for an impulse input is...
343
Applications of RC Circuits
3.3K
A relaxation oscillator is one of the applications of RC circuits. A neon lamp relaxation oscillator comprises a capacitor, a resistor, a voltage source, and a lamp. The lamp acts like an open circuit, with infinite resistance until the potential difference across the lamp reaches a specific voltage. At that voltage, the lamp acts like a short circuit with zero resistance, and the capacitor discharges through the lamp, thus producing light. Once the capacitor is fully discharged through the...
3.3K
Deconvolution
246
Deconvolution, also known as inverse filtering, is the process of extracting the impulse response from known input and output signals. This technique is vital in scenarios where the system's characteristics are unknown, and they must be inferred from the observable signals.
Deconvolution involves several mathematical techniques to derive the impulse response. One common approach is polynomial division. In this method, the input and output sequences are treated as coefficients of...
Deconvolution involves several mathematical techniques to derive the impulse response. One common approach is polynomial division. In this method, the input and output sequences are treated as coefficients of...
246
Op Amp AC Circuits
271
Within an audio system, the filter circuit plays a pivotal role in processing the amplified audio signal from an amplifier. Its primary function is significantly attenuating signal components with lower frequencies, thereby shaping the audio output. This circuit's operations are examined, focusing on the fundamental filter configuration. This configuration involves an operational amplifier arranged in an inverting setup coupled with resistors (R1 and R2) and a capacitor (C1).
271


