在接受血造干细胞移植的儿科患者中使用静脉注射的波萨可纳
Carolyn Kusoski1, Parinda A Mehta2, Justin Markham3
1Division of Pharmacy, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Transplantation and cellular therapy
|September 5, 2025
概括
在儿童造血干细胞移植 (HSCT) 患者中,静脉注射的波萨可纳有效达到菌感染预防和治疗的目标水平. 10 mg/ kg的加重剂量,随后的维持剂量被证明是安全有效的,肝功能障碍是最常见的不良反应.
科学领域:
- 药理学
- 血液学
- 传染性疾病
背景情况:
- 小儿造血干细胞移植 (HSCT) 患者面临侵入性真菌感染的高风险.
- 由于胃肠道问题,传统的口服波萨可纳在HSCT患者中具有不可靠的吸收能力.
- 静脉注射 (IV) 波萨可纳对于治疗这种脆弱群体的真菌感染至关重要.
研究的目的:
- 评估Posaconazole在儿童HSCT感染的预防和治疗中的安全性和有效性.
- 确定最佳的剂量策略,以达到可纳的目标水平.
- 在该群体中确定与静脉可纳使用相关的不良事件.
主要方法:
- 在2015年1月至2023年8月期间接受静脉注射波萨可纳的儿科HSCT患者的回顾性病理表.
- 对剂量方案的分析,达到药物度的目标和临床结果.
- 对不良事件的评估,特别是肝功能障碍.
主要成果:
- 96. 3% 的患者在一次疗程内达到标水平.
- 基于体重的10 mg/ kg的中位数剂量对预防和治疗都有效.
- 肝功能障碍是最常见的不良事件 (86%的中止),但许多患者可以重新开始治疗.
结论:
- 对于小儿高血压治疗患者,初始治疗方案是每12小时服用10 mg/ kg的两剂,然后每24小时服用10 mg/ kg.
- 静脉可纳具有良好的安全性,肝功能障碍是可以控制的.
- 这项研究是迄今为止对小儿高血压瘤治疗的最大评估.
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