从胰腺管腺癌预测放射性隐形转移性疾病的危险因素:常规手术前磁共振成像的单一机构经验
Sibi Krishna Thiyagarajan1, Kareem Sadek2, Alfredo Verastegui1
1Department of Surgery, Mayo Clinic, Jacksonville, Florida.
概括
放射性隐性转移性疾病 (ROMD) 在4. 1%的患者中导致胰腺手术中断. 边缘切除/局部发达的胰腺管腺癌 (PDAC) 是ROMD的主要预测因子,突出显示了需要高级成像.
科学领域:
- 癌症学
- 外科瘤学
- 胃肠病学
背景情况:
- 由于放射性隐性转移性疾病 (ROMD) 导致的胰腺手术中断的发生率存在有限的数据.
- 胰腺管腺癌 (PDAC) 手术是复杂的,手术前成像对计划至关重要.
- 了解ROMD风险因素对于防止不必要的手术至关重要.
研究的目的:
- 在接受手术前MRI的PDAC患者中确定ROMD的危险因素.
- 评估在一个机构中由于ROMD而导致的胰腺手术中断的发生率.
- 评估ROMD临床和放射学因素的预测价值.
主要方法:
- 在2012年至2022年间接受PDAC手术的440名患者的回顾性评估.
- 鉴定由于ROMD而中止手术的患者.
- 用二进制逻辑回归分析来确定ROMD的预测因素.
主要成果:
- 18名患者 (4. 1%) 由于ROMD而中止手术.
- 单变量分析显示年龄较小,BMI较低,体重减轻,瘤大小较大以及边缘切除/局部晚期 (BR/LA) 疾病是危险因素.
- 多变量分析发现BR/LA疾病是ROMD的唯一独立预测因子 (P=0.002).
- ROMD与手术前的癌症抗原 (CA) 19-9水平没有关联.
结论:
- 患有BR/ LA甚至可切除PDAC的患者面临ROMD风险,最常见的是肝转移.
- BR/LA疾病,年轻年龄,低BMI和较大的瘤大小可能预测较高的ROMD风险.
- 手术前的MRI可以帮助减少ROMD的发生率和不必要的PDAC手术.
相关概念视频
Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
Radiological Investigation II: MRI and Ventilation Perfusion Scan
Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
Radiological Investigation III: Pulmonary Angiogram and PET Scan
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Imaging Studies I: CT and MRI
Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Imaging Studies for Cardiovascular System IV: CMRI
Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
Imaging Studies IV: Magnetic Resonance Imaging
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...


