母性聚烯纳米塑料通过线粒体功能障碍抑制斑马鱼后代的发育和运动
Fangjie Cao1, Bingyue Liu2, Xinran Hou3
1National-Regional Joint Engineering Research Center for Soil Pollution Control and Remediation in South China, Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and Management, Institute of Eco-environmental and Soil Sciences, Guangdong Academy of Sciences, Guangzhou 510650, China.
Environmental pollution (Barking, Essex : 1987)
|September 5, 2025
概括
母亲接触到聚乙烯纳米塑料 (PS-NP) 会影响斑马鱼后代的发育和运动. 这发生在线粒体能量代谢和氧化酸化途径中断,影响跨代健康.
科学领域:
- 环境毒理学
- 水生生态毒理学
- 纳米毒理学
背景情况:
- 塑料污染,尤其是纳米塑料,是水生生态系统的普遍威胁.
- 已知母体转移的聚烯纳米塑料 (PS-NP) 会影响后代的发育.
- 这些跨代效应背后的分子机制尚不清楚.
研究的目的:
- 阐明母体PS-NP暴露破坏斑马鱼后代胚胎发育和运动的机制.
- 调查线粒体功能障碍在这些跨代影响中的具体作用.
- 评估环境相关的PS-NP度的影响.
主要方法:
- 在120天的时间里,斑马鱼的母体暴露在1-100μg/L的度下.
- 评估后代的发育 (头部区域,身体长度,形) 和行为 (运动) 终点.
- 对线粒体呼吸,转录组学 (专注于氧化酸化) 和蛋白质与蛋白质相互作用网络的分析.
主要成果:
- 母亲的PS-Eu暴露显著减少了后代的头部面积和身体长度,并增加了10和100μg/L的发育不良.
- 在母亲暴露于10和100μg/ LPS- Eu后,后代的运动明显受阻.
- 母亲暴露于100μg/L的PS-Eu抑制了后代的线粒体呼吸,并降低了关键的氧化酸化基因,称为枢纽基因 (例如,atp5po,uqcrq).
结论:
- 通过破坏线粒体能量代谢,孕产妇接触PS- NPs会抑制斑马鱼后代的胚胎发育和运动.
- 抑制氧化化途径是推动这些跨代毒性作用的关键分子机制.
- 这项研究为纳米塑料的毒性提供了关键的机制见解,为水生物种的环境风险评估提供了信息.
相关概念视频
01:07Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
01:22Gut-Brain Axis
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...