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在精神分裂症中表征 interthalamic 粘附形态:与衰老,神经心理功能和非典型的海马发育相关

Zachary Bergson¹, Maxwell J Roeske¹, Baxter P Rogers²

¹Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center.

Biological psychiatry. Cognitive neuroscience and neuroimaging

|September 5, 2025

概括

精神分裂症谱系障碍 (SSD) 中的甲状腺粘附 (IA) 尺寸较小,并且随着年龄的增长而减少,这表明疾病进展而不是发育问题. 缺少IA与不完整的海马逆转有关,表明共享的神经发育障碍.

科学领域:

神经成像
发展神经科学
精神病学

背景情况:

在怀孕的第二个三个月内形成的thalamic粘附 (IA) 连接thalami.
较小或不存在的IA与精神分裂症和认知缺陷等神经发育障碍有着不一致的联系.
在精神分裂症中,IA形态与其他发育变异,如不完全的海马逆转 (IHI) 之间的关系尚不清楚.

研究的目的:

与健康对照组相比,研究精神分裂谱系障碍 (SSD) 个体的thalamic粘附 (IA) 的存在,形态和大小.
在SSD中检查IA形态,认知功能和不完整的海马逆转 (IHI) 之间的关联.
澄清SSD中的IA大小差异是否反映早期神经发育异常或晚期疾病相关变化.

主要方法:

在223名SSD患者和194名健康患者中使用结构T1权重的MRI扫描来评估IA的存在/缺席和形态.
在SSD和对照组之间进行了IA特征的比较.
统计分析探讨了IA形态,年龄,诊断,IHI和神经认知表现之间的相关性.

主要成果:

缺失IA的患病率很低 (1.7%),并且在不同组之间相似.
在SSD患者中,IA大小显著减少.
这种较小的SSDIA大小主要是由于诊断与年龄的显著相互作用,这表明SSD组的IA大小与年龄相关的下降.
在缺失IA的患者中,不完整的海马逆转 (IHI) 显著更为普遍.
在对年龄和诊断进行控制后,神经认知与IA大小没有直接相关.

结论:

在SSD群体内IA大小的年龄依赖性减少表明它可能反映疾病进展或加快衰老,而不是早期神经发育异常的静态标志.
缺少IA,虽然很少见,与IHI有关,这表明怀孕第二个三个月期间可能存在潜在的神经发育障碍.
这些发现突显了SSD中IA形态的动态性质及其与其他神经发育变异的潜在联系.

关键词:

认知能力海马甲状腺之间的粘附神经发育精神分裂症其他

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