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孕期多乙烯 (PBDE) 血清度与2至8岁儿童睡眠结果之间的关联

Kelli Williams¹, Jagadeesh Puvvula¹, John H Holmes¹

¹Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.

Environmental research

|September 5, 2025

概括

孕期暴露于多二乙烯 (PBDE) 与儿童睡眠不规则性和睡眠中断的增加有关. 这项研究强调了潜在的睡眠障碍是PBDE相关的神经行为问题的一个因素.

科学领域:

环境健康
儿童睡眠医学
毒理学

背景情况:

孕期暴露于多二乙烯 (PBDE) 是已知的内分泌干扰物,与母亲的甲状腺问题和儿童的神经行为影响有关.
产前PBDE暴露对儿童睡眠模式的影响在很大程度上尚不清楚.

研究的目的:

研究2至8岁儿童在孕期暴露于特定PBDE原体和各种睡眠参数之间的关联.
探索产前PBDE水平与儿童睡眠不规则,超眠,睡眠障碍和睡眠时间之间的纵向关系.

主要方法:

采用了410个母婴对象的健康结果和环境测量 (HOME) 研究数据.
通过适应的儿童睡眠健康问卷测量妊娠期血清PBDE水平 (包括PBDE-153, -100, -99, -47, -28和 ΣPBDE) 和儿童睡眠模式.
使用通用估计方程来评估纵向关联,并调整相关共变量.

主要成果:

在所有观察年份中,孕期PBDE-99,PBDE-47和SPBDE与睡眠不规则的增加有关.
在5岁和8岁时,PBDE-28暴露与更高的睡眠不规则有关.
随着时间的推移,PBDE-47,PBDE- 99和SPBDE与儿童睡眠障碍的增加有关.
在妊娠期的PBDE和儿童的睡眠时间之间没有发现显著的关联.

结论:

产前接触某些PBDE与儿童的睡眠不规则性和睡眠中断有关.
睡眠障碍可能是与孕期PBDE暴露相关的神经行为影响的关键调解者.
需要进一步研究以了解这些发现对儿童发育的机制和影响.

关键词:

孩子的睡眠内分泌干扰剂阻燃剂聚二乙烯 (PBDE)一次性暴露

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